El Gigante (Plaga)
Created by Plaga implantation (the parasites formerly confined beneath Salazar Castle) and genetic manipulation, El Gigante, as its Spanish name suggests, is four times the size of a normal human being. Although it is endowed with incredible strength and endurance, its intelligence is severely impaired—Ganados that fail to keep their distance are often killed in its blind rage, and few Gigantes have been created due to this uncontrollable brutality.
Gigantes are encountered in three memorable battles in RE4. The first encounter stands out due to the sheer impact of seeing the Gigante for the first time, and the dog that heroically appears (depending on the player's previous actions) to distract the Gigante will have no doubt brought a smile to many. The third encounter, which sees the player face two Gigantes at once, is also surely etched into the minds of many players. While it isn't necessary to defeat the Gigante that appears during the second encounter, hardcore RE4 players will want to take it down for the large peseta drop.