Resident Evil 2
Wife of William Birkin. A fellow researcher at Umbrella, she assists in her husband's research. Completely absorbed in their work, both parents neglected their daughter Sherry.
When William mutates into the creature called G, losing his mind, Annette realizes the damage they had done to their own family, and decides to defeat G if only for Sherry's sake. She suffers a fatal wound from her frenzied former husband.