A B.O.W. that first appeared in the Republic of Edonia. The name derives from the Serbian word for "gigantic," and given the way that they tower over roofs and smash through buildings while chasing Chris and Piers, it's easy to see how this name was earned. Ogromen can be dropped from helicopters by suspending them from the plug-like protrusion on their backs, but once deployed the plug remains and is decidedly weaker compared to the Ogroman's hard skin.
Previous gigantic B.O.W.s, including El Gigante from RE4 and Ndesu from RE5, were created using Plaga parasites. These Plagas would reveal themselves each time a certain amount of damage was dealt.