Albert Wesker (RE5)
Wesker first appeared as the resourceful S.T.A.R.S. captain in the original RE. He was revealed to be an Umbrella spy sent to infiltrate the team, but ultimately he betrays even Umbrella. While appearing to die towards the end of the game, he continues to operate in the shadows thereafter and is involved in a number of B.O.W. incidents and virus thefts over the years. His fate is sealed by his rival Chris in RE5, but the effects of Wesker's actions linger beyond the grave.
As the principal villain for much of the series, there is plenty of Wesker artwork. The artwork below was produced for the following games (l-r): Resident Evil (GC), Resident Evil Code: Veronica X, Resident Evil 5 (the image at the top is from RE0). Wesker has a consistently menacing appearance throughout the series: sunglasses, combed blond hair, and dark clothes.